| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Who Framed Roger Rabbit (1988) | £1,506,863 | £1,506,863 | £1,506,863 | new | 1 |
| 2 (1) |  | Scrooged (1988) | £614,458 | £860,241 | £1,408,453 | 11% | 2 |
| 3 (new) |  | The Bedroom Window (1988) | £189,606 | £189,606 | £189,606 | new | 1 |
| 4 (3) |  | Cocoon: The Return (1988) | £88,324 | £119,237 | £269,387 | -41% | 2 |
| 5 (2) |  | Tucker: The Man and His Dream (1988) | £85,288 | £123,668 | £642,221 | -47% | 3 |
| 6 (4) |  | A Fish Called Wanda (1988) | £74,045 | £103,663 | £6,053,796 | -47% | 8 |
| 7 (5) |  | Colors (1988) | £61,825 | £83,464 | £967,402 | -47% | 4 |
| 8 (6) | | The Hidden (1988) | £39,992 | £57,988 | £137,971 | -50% | 2 |
| 9 (7) |  | Big (1988) | £32,238 | £45,133 | £2,896,824 | -47% | 7 |
| 10 (8) |  | Buster (1988) | £15,937 | £20,718 | £4,038,921 | -50% | 12 |
| 11 (11) |  | Midnight Run (1988) | £9,784 | £14,187 | £1,487,307 | -9% | 9 |
| 12 (9) |  | Stormy Monday (1988) | £9,149 | £11,894 | £135,405 | -50% | 4 |
| 13 (12) |  | Good Morning Vietnam (1988) | £4,438 | £5,991 | £3,289,506 | -50% | 10 |
| 14 (10) | | Patty Hearst (1988) | £4,303 | £5,809 | £43,848 | -62% | 3 |