| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | You, Me and Dupree (2006) | £1,636,249 | £1,636,249 | £1,636,249 | new | 1 |
| 2 (1) |  | Snakes On a Plane (2006) | £698,166 | £1,592,252 | £2,661,860 | -35% | 2 |
| 3 (3) |  | Pirates of the Caribbean: Dead Man's Chest (2006) | £631,287 | £1,447,155 | £49,852,804 | -30% | 8 |
| 4 (2) |  | Cars (2006) | £556,581 | £1,421,744 | £14,242,320 | -41% | 5 |
| 5 (4) |  | Monster House (2006) | £527,181 | £1,394,847 | £4,497,314 | -38% | 3 |
| 6 (5) |  | John Tucker Must Die (2006) | £509,219 | £1,451,353 | £2,296,986 | -40% | 2 |
| 7 (new) |  | Severance (2006) | £483,152 | £483,152 | £483,152 | new | 1 |
| 8 (new) |  | Volver (2006) | £433,283 | £433,283 | £433,283 | new | 1 |
| 9 (7) |  | Miami Vice (2006) | £325,431 | £742,416 | £6,873,370 | -46% | 4 |
| 10 (6) |  | Nacho Libre (2006) | £306,134 | £837,956 | £3,297,259 | -50% | 3 |
| 11 (9) |  | Garfield 2 (2006) | £242,748 | £604,444 | £5,347,014 | -18% | 6 |
| 12 (8) |  | Kabhi Alvida Naa Kehna (2006) | £159,392 | £333,920 | £1,773,810 | -48% | 3 |
| 13 (10) |  | The Break Up (2006) | £140,569 | £400,939 | £10,049,790 | -51% | 6 |
| 14 (12) |  | A Scanner Darkly (2006) | £129,632 | £318,717 | £561,707 | -47% | 2 |
| 15 (13) |  | Superman Returns (2006) | £126,064 | £301,096 | £15,727,425 | -38% | 7 |