| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Talladega Nights: The Ballad of Ricky Bobby (2006) | £1,033,759 | £1,033,759 | £1,033,759 | new | 1 |
| 2 (new) |  | The Queen (2006) | £856,273 | £856,273 | £856,273 | new | 1 |
| 3 (new) |  | The Black Dahlia (2006) | £566,874 | £566,874 | £566,874 | new | 1 |
| 4 (1) |  | You, Me and Dupree (2006) | £562,757 | £935,557 | £6,792,009 | -25% | 4 |
| 5 (2) |  | Little Man (2006) | £556,406 | £765,669 | £3,058,589 | -17% | 3 |
| 6 (5) |  | Little Miss Sunshine (2006) | £391,415 | £679,927 | £1,029,737 | 11% | 2 |
| 7 (new) |  | The Night Listener (2006) | £314,078 | £314,078 | £314,078 | new | 1 |
| 8 (new) | | DOA: Dead Or Alive (2006) | £224,786 | £224,786 | £224,786 | new | 1 |
| 9 (4) |  | The Sentinel (2006) | £198,475 | £421,213 | £1,793,938 | -49% | 3 |
| 10 (3) |  | Right At Your Door (2006) | £188,049 | £422,374 | £863,922 | -57% | 2 |
| 11 (12) |  | Monster House (2006) | £166,160 | £193,270 | £6,205,700 | -16% | 6 |
| 12 (8) |  | Volver (2006) | £163,113 | £346,975 | £2,086,398 | -32% | 4 |
| 13 (13) |  | Cars (2006) | £151,523 | £187,312 | £15,977,450 | -16% | 8 |
| 14 (9) |  | Pirates of the Caribbean: Dead Man's Chest (2006) | £150,014 | £257,128 | £51,735,498 | -34% | 11 |
| 15 (7) |  | Crank (2006) | £123,594 | £289,651 | £1,279,643 | -52% | 3 |
| 16 (16) |  | Snow Cake (2006) | £36,329 | £36,329 | £108,986 | -50% | 2 |
| 17 (re) |  | Thank You For Smoking (2006) | £2,814 | £2,814 | £1,528,350 | RE | 12 |
| 18 (re) |  | Tideland (2006) | £2,588 | £2,588 | £66,125 | RE | 4 |