| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Happy Feet (2006) | £3,689,166 | £3,689,166 | £3,689,166 | new | 1 |
| 2 (new) |  | The Holiday (2006) | £2,826,520 | £2,826,520 | £2,826,520 | new | 1 |
| 3 (1) |  | Casino Royale (2006) | £2,741,362 | £4,873,290 | £41,960,147 | -48% | 4 |
| 4 (2) |  | Flushed Away (2006) | £1,221,231 | £1,667,264 | £4,774,138 | -61% | 2 |
| 5 (3) |  | The Santa Clause 3: The Escape Clause (2006) | £734,041 | £983,444 | £3,657,890 | -27% | 3 |
| 6 (5) |  | Deck the Halls (2006) | £370,126 | £581,881 | £1,181,928 | -38% | 2 |
| 7 (4) |  | Borat: Cultural Learnings of America For Make Benefit Glorious Nation of Kazakhstan (2006) | £336,350 | £667,281 | £23,366,518 | -57% | 6 |
| 8 (new) |  | Baabul (2006) | £289,894 | £289,894 | £289,894 | new | 1 |
| 9 (new) |  | The Covenant (2006) | £181,365 | £181,365 | £181,365 | new | 1 |
| 10 (9) |  | Pans Labyrinth (2006) | £178,183 | £339,862 | £1,104,320 | -28% | 3 |
| 11 (7) |  | Stranger Than Fiction (2006) | £132,346 | £334,332 | £702,959 | -64% | 2 |
| 12 (6) |  | Tenacious D In the Pick of Destiny (2006) | £100,350 | £278,209 | £1,959,140 | -74% | 3 |
| 13 (new) |  | The Nativity Story (2006) | £78,553 | £78,553 | £78,553 | new | 1 |
| 14 (10) |  | Dhoom 2 (2006) | £78,405 | £157,301 | £1,039,223 | -67% | 3 |
| 15 (8) |  | Jackass Number Two (2006) | £72,787 | £224,066 | £1,684,673 | -77% | 3 |
| 16 (16) | | London to Brighton (2006) | £36,060 | £63,275 | £101,768 | -6% | 2 |