| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Avatar (2009) | £5,155,844 | £8,066,607 | £57,441,123 | -7% | 6 |
| 2 (2) |  | Sherlock Holmes (2009) | £1,632,172 | £2,543,366 | £21,372,499 | -20% | 5 |
| 3 (3) |  | Alvin and the Chipmunks: The Squeakquel (2009) | £1,454,278 | £1,700,521 | £18,563,223 | -6% | 5 |
| 4 (5) |  | Up In the Air (2009) | £1,205,881 | £1,984,489 | £3,282,512 | -7% | 2 |
| 5 (4) |  | Its Complicated (2009) | £1,140,684 | £2,106,396 | £5,397,653 | -12% | 3 |
| 6 (re) |  | Toy Story 2 (1999) | £909,093 | £909,093 | £44,400,114 | RE | 13 |
| 7 (6) |  | The Book of Eli (2010) | £825,508 | £1,404,077 | £2,636,078 | -33% | 2 |
| 8 (7) |  | Daybreakers (2009) | £420,199 | £784,583 | £3,521,958 | -48% | 3 |
| 9 (new) |  | Brother's (2010) | £366,290 | £366,290 | £366,290 | new | 1 |
| 10 (new) | | A Prophet (2010) | £312,237 | £312,237 | £312,237 | new | 1 |
| 11 (8) |  | The Road (2010) | £255,486 | £494,375 | £2,004,350 | -46% | 3 |
| 12 (9) |  | Did You Hear About the Morgans? (2010) | £198,931 | £373,464 | £3,339,675 | -50% | 4 |
| 13 (10) |  | St. Trinian's 2: The Legend of Frittons Gold (2009) | £197,615 | £242,968 | £6,788,842 | -30% | 6 |
| 14 (new) |  | Ninja Assassin (2010) | £187,285 | £187,285 | £187,285 | new | 1 |
| 15 (new) |  | Veer (2010) | £148,423 | £148,423 | £148,423 | new | 1 |