| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Valentine's Day (2010) | £3,732,393 | £3,732,393 | £3,732,393 | new | 1 |
| 2 (1) |  | Avatar (2009) | £3,316,855 | £5,136,271 | £77,072,663 | -24% | 9 |
| 3 (new) |  | The Wolfman (2010) | £2,367,849 | £2,367,849 | £2,367,849 | new | 1 |
| 4 (2) |  | The Princess and the Frog (2010) | £1,504,908 | £1,957,636 | £4,197,395 | -33% | 3 |
| 5 (new) |  | Percy Jackson and the Olympians: The Lightning Thief (2010) | £1,502,663 | £1,502,663 | £1,502,663 | new | 1 |
| 6 (new) |  | My Name Is Khan (2010) | £936,454 | £936,454 | £936,454 | new | 1 |
| 7 (4) |  | Invictus (2009) | £778,146 | £1,394,180 | £2,462,568 | -27% | 2 |
| 8 (new) |  | A Single Man (2010) | £502,009 | £502,009 | £502,009 | new | 1 |
| 9 (8) |  | Alvin and the Chipmunks: The Squeakquel (2009) | £424,622 | £500,018 | £21,337,049 | -42% | 8 |
| 10 (3) |  | Astro Boy (2009) | £422,382 | £534,115 | £1,625,987 | -61% | 2 |
| 11 (5) |  | Sherlock Holmes (2009) | £391,913 | £688,509 | £25,162,902 | -50% | 8 |
| 12 (7) |  | Youth In Revolt (2010) | £368,019 | £746,250 | £1,490,182 | -51% | 2 |
| 13 (6) |  | Edge of Darkness (2010) | £301,086 | £651,316 | £3,302,594 | -61% | 3 |
| 14 (9) |  | Its Complicated (2009) | £200,720 | £549,103 | £8,838,051 | -64% | 6 |
| 15 (11) |  | Precious: Based On the Novel Push By Sapphire (2009) | £181,714 | £398,654 | £1,211,445 | -51% | 3 |