| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Date Night (2010) | £1,272,405 | £1,272,405 | £1,272,405 | new | 1 |
| 2 (2) |  | Clash of the Titans (2010) | £985,344 | £1,797,236 | £18,070,779 | -37% | 4 |
| 3 (3) |  | How to Train Your Dragon (2010) | £821,638 | £1,167,572 | £14,256,991 | -36% | 4 |
| 4 (1) |  | Dear John (2010) | £812,287 | £1,581,342 | £3,576,643 | -59% | 2 |
| 5 (4) |  | Kick-Ass (2010) | £635,270 | £1,200,546 | £10,241,210 | -30% | 4 |
| 6 (6) |  | The Ghost (2010) | £631,032 | £1,193,859 | £2,047,538 | -26% | 2 |
| 7 (new) |  | It's a Wonderful Afterlife (2010) | £464,468 | £464,468 | £464,468 | new | 1 |
| 8 (5) |  | Nanny Mcphee and the Big Bang (2010) | £397,371 | £602,728 | £15,169,311 | -54% | 5 |
| 9 (7) |  | Alice In Wonderland (2010) | £278,855 | £492,517 | £41,915,826 | -44% | 8 |
| 10 (new) |  | The Joneses (2009) | £247,178 | £247,178 | £247,178 | new | 1 |
| 11 (re) |  | Cemetery Junction (2010) | £202,587 | £202,587 | £1,132,948 | RE | 1 |
| 12 (8) |  | The Blind Side (2010) | £131,153 | £303,499 | £5,933,635 | -56% | 5 |
| 13 (new) |  | Centurion (2010) | £114,147 | £114,147 | £114,147 | new | 1 |
| 14 (11) |  | Shutter Island (2010) | £82,495 | £168,627 | £10,599,763 | -54% | 7 |
| 15 (9) |  | Remember Me (2010) | £70,866 | £208,729 | £3,572,119 | -69% | 4 |