| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Get Him to the Greek (2010) | £1,569,556 | £1,569,556 | £1,569,556 | new | 1 |
| 2 (1) |  | Killers (2010) | £389,509 | £810,762 | £1,863,836 | -63% | 2 |
| 3 (2) |  | Sex and the City 2 (2010) | £357,066 | £976,846 | £20,353,171 | -50% | 5 |
| 4 (4) |  | Prince of Persia: The Sands of Time (2010) | £159,684 | £321,258 | £8,356,964 | -59% | 6 |
| 5 (3) |  | StreetDance 3D (2010) | £159,260 | £319,486 | £11,280,062 | -66% | 6 |
| 6 (6) |  | Death At a Funeral (2010) | £118,648 | £286,569 | £2,414,942 | -59% | 4 |
| 7 (new) | | The Collector (2010) | £109,519 | £109,519 | £109,519 | new | 1 |
| 8 (5) |  | Letters to Juliet (2010) | £104,134 | £307,038 | £1,770,149 | -66% | 3 |
| 9 (9) |  | Robin Hood (2010) | £89,457 | £218,111 | £15,104,421 | -63% | 7 |
| 10 (7) |  | Wild Target (2010) | £88,287 | £260,836 | £543,334 | -69% | 2 |
| 11 (8) |  | Tooth Fairy (2010) | £78,171 | £124,360 | £3,499,833 | -69% | 5 |
| 12 (10) |  | Brooklyn's Finest (2010) | £76,274 | £189,182 | £1,125,050 | -62% | 3 |
| 13 (new) | | Whatever Works (2010) | £72,678 | £72,678 | £72,678 | new | 1 |
| 14 (new) |  | When In Rome (2010) | £61,512 | £61,512 | £61,512 | new | 1 |
| 15 (11) |  | Raavan (2010) | £27,230 | £74,905 | £200,035 | -78% | 2 |