| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Shrek Forever After (2010) | £8,955,554 | £8,955,554 | £8,955,554 | new | 1 |
| 2 (1) |  | Get Him to the Greek (2010) | £1,048,898 | £2,292,057 | £3,861,613 | -33% | 2 |
| 3 (2) |  | Killers (2010) | £274,768 | £642,693 | £2,506,529 | -29% | 3 |
| 4 (3) |  | Sex and the City 2 (2010) | £212,501 | £635,592 | £20,988,763 | -40% | 6 |
| 5 (new) |  | I Hate Luv Storys (2010) | £202,907 | £202,907 | £202,907 | new | 1 |
| 6 (new) | | Heartbreaker (2010) | £119,742 | £119,742 | £119,742 | new | 1 |
| 7 (4) |  | Prince of Persia: The Sands of Time (2010) | £92,682 | £256,738 | £8,613,702 | -42% | 7 |
| 8 (6) |  | Death At a Funeral (2010) | £68,609 | £213,239 | £2,628,181 | -42% | 5 |
| 9 (7) | | The Collector (2010) | £65,042 | £203,301 | £312,820 | -41% | 2 |
| 10 (13) | | Whatever Works (2010) | £49,321 | £130,877 | £203,555 | -32% | 2 |
| 11 (9) |  | Robin Hood (2010) | £45,899 | £191,115 | £15,295,536 | -49% | 8 |
| 12 (11) |  | Tooth Fairy (2010) | £45,135 | £97,434 | £3,597,267 | -42% | 6 |
| 13 (5) |  | StreetDance 3D (2010) | £43,797 | £208,138 | £11,488,200 | -72% | 7 |
| 14 (8) |  | Letters to Juliet (2010) | £42,451 | £198,387 | £1,968,536 | -59% | 4 |
| 15 (12) |  | Brooklyn's Finest (2010) | £38,973 | £127,554 | £1,252,604 | -49% | 4 |