| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | The Other Guys (2010) | £1,980,601 | £1,980,601 | £1,980,601 | new | 1 |
| 2 (new) |  | Devil (2010) | £807,292 | £807,292 | £807,292 | new | 1 |
| 3 (1) |  | Resident Evil: Afterlife (2010) | £727,908 | £1,640,185 | £3,330,840 | -57% | 2 |
| 4 (2) |  | Toy Story 3 (2010) | £583,013 | £792,800 | £71,807,948 | -23% | 9 |
| 5 (3) |  | Grown Ups (2010) | £513,881 | £855,617 | £6,300,322 | -31% | 4 |
| 6 (5) |  | Tamara Drewe (2010) | £432,337 | £932,628 | £1,548,181 | -30% | 2 |
| 7 (4) |  | The Last Exorcism (2010) | £321,585 | £689,264 | £3,180,800 | -56% | 3 |
| 8 (13) |  | Marmaduke (2010) | £279,392 | £147,986 | £4,686,910 | -9% | 5 |
| 9 (new) | | Winter's Bone (2010) | £267,408 | £267,408 | £267,408 | new | 1 |
| 10 (15) |  | Diary of a Wimpy Kid (2010) | £241,390 | £265,456 | £2,058,757 | -9% | 4 |
| 11 (6) |  | Scott Pilgrim Vs. the World (2010) | £233,228 | £473,543 | £4,812,773 | -47% | 4 |
| 12 (7) |  | Going the Distance (2010) | £220,359 | £593,015 | £1,029,376 | -50% | 2 |
| 13 (14) |  | Inception (2010) | £201,162 | £367,112 | £34,976,999 | -26% | 10 |
| 14 (11) |  | Salt (2010) | £190,011 | £388,356 | £6,737,499 | -45% | 5 |
| 15 (8) |  | Cyrus (2010) | £172,584 | £488,811 | £918,730 | -60% | 2 |