| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | The Other Guys (2010) | £1,292,144 | £2,427,145 | £4,407,746 | -35% | 2 |
| 2 (new) |  | Eat Pray Love (2010) | £1,165,234 | £1,165,234 | £1,165,234 | new | 1 |
| 3 (new) |  | The Town (2010) | £1,005,039 | £1,005,039 | £1,005,039 | new | 1 |
| 4 (new) |  | The Hole (2010) | £906,722 | £906,722 | £906,722 | new | 1 |
| 5 (2) |  | Devil (2010) | £528,908 | £1,042,717 | £1,850,009 | -34% | 2 |
| 6 (4) |  | Toy Story 3 (2010) | £472,449 | £603,277 | £72,411,225 | -19% | 10 |
| 7 (5) |  | Grown Ups (2010) | £384,119 | £604,839 | £6,905,161 | -25% | 5 |
| 8 (3) |  | Resident Evil: Afterlife (2010) | £367,675 | £793,937 | £4,124,777 | -49% | 3 |
| 9 (6) |  | Tamara Drewe (2010) | £245,643 | £555,778 | £2,103,959 | -43% | 3 |
| 10 (8) |  | Marmaduke (2010) | £244,285 | £125,223 | £4,812,133 | -13% | 6 |
| 11 (10) |  | Diary of a Wimpy Kid (2010) | £205,241 | £228,647 | £2,287,404 | -15% | 5 |
| 12 (13) |  | Inception (2010) | £174,186 | £287,404 | £35,264,403 | -13% | 11 |
| 13 (7) |  | The Last Exorcism (2010) | £162,133 | £326,755 | £3,507,555 | -50% | 4 |
| 14 (11) |  | Scott Pilgrim Vs. the World (2010) | £142,180 | £268,408 | £5,081,181 | -39% | 5 |
| 15 (9) | | Winter's Bone (2010) | £126,865 | £300,837 | £568,245 | -53% | 2 |