| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | The Chronicles of Narnia: The Voyage of the Dawn Treader (2010) | £2,460,118 | £2,460,118 | £2,460,118 | new | 1 |
| 2 (1) |  | Harry Potter and the Deathly Hallows Part 1 (2010) | £1,905,368 | £3,425,326 | £42,570,440 | -49% | 4 |
| 3 (new) |  | The Tourist (2010) | £1,341,143 | £1,341,143 | £1,341,143 | new | 1 |
| 4 (2) |  | Megamind (2010) | £1,205,320 | £1,717,902 | £4,545,404 | -57% | 2 |
| 5 (3) |  | Unstoppable (2010) | £406,882 | £843,511 | £3,989,854 | -53% | 3 |
| 6 (4) |  | Due Date (2010) | £192,311 | £443,631 | £10,303,604 | -51% | 6 |
| 7 (5) |  | Monsters (2010) | £154,743 | £346,672 | £695,249 | -56% | 2 |
| 8 (new) |  | Somewhere (2010) | £125,581 | £125,581 | £125,581 | new | 1 |
| 9 (new) | | No Problem (2010) | £114,652 | £114,652 | £114,652 | new | 1 |
| 10 (6) |  | The American (2010) | £109,084 | £263,002 | £1,184,528 | -62% | 3 |
| 11 (8) |  | Despicable Me (2010) | £66,705 | £223,197 | £19,670,786 | -51% | 9 |
| 12 (7) |  | London Boulevard (2010) | £58,572 | £207,120 | £1,267,625 | -77% | 3 |
| 13 (11) |  | Of Gods and Men (2010) | £54,368 | £95,717 | £155,096 | -8% | 2 |
| 14 (9) |  | The Girl Who Kicked the Hornets Nest (2010) | £45,457 | £117,255 | £556,016 | -60% | 3 |
| 15 (re) |  | A Christmas Carol (2009) | £32,667 | £32,667 | £20,371,281 | RE | 10 |
| 16 (new) | | Band Baaja Baaraat (2010) | £24,675 | £24,675 | £24,675 | new | 1 |
| 17 (15) |  | Another Year (2010) | £13,720 | £44,248 | £1,567,557 | -61% | 6 |
| 18 (new) |  | For Colored Girls (2010) | £10,956 | £10,956 | £10,956 | new | 1 |
| 19 (new) | | On Tour (2010) | £4,822 | £4,822 | £4,822 | new | 1 |
| 20 (new) | | Enemies of the People (2010) | £2,289 | £2,289 | £2,289 | new | 1 |
| 21 (new) | | Thorn In the Heart (2010) | £2,088 | £2,088 | £2,088 | new | 1 |
| 22 (20) |  | Made In Dagenham (2010) | £1,503 | £11,550 | £3,657,808 | -71% | 11 |
| 23 (22) |  | Burke and Hare (2010) | £1,285 | £5,645 | £2,344,716 | -65% | 6 |
| 24 (27) | | Robinson In Ruins (2010) | £929 | £1,893 | £14,452 | 5% | 2 |
| 25 (29) | | The Illusionist (2010) | £616 | £2,251 | £908,842 | -12% | 16 |
| 26 (28) | | The Arbor (2010) | £472 | £576 | £60,549 | -43% | 8 |
| 27 (24) | | Africa United (2010) | £445 | £2,090 | £673,017 | -72% | 8 |
| 28 (32) |  | Mr. Nice (2010) | £428 | £2,878 | £766,779 | 74% | 10 |
| 29 (new) | | Outcast (2010) | £113 | £113 | £113 | new | 1 |