| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Gullivers Travels (2010) | £7,028,747 | £7,028,747 | £7,028,747 | new | 1 |
| 2 (1) |  | Little Fockers (2010) | £2,614,802 | £8,123,918 | £11,159,635 | -14% | 2 |
| 3 (new) |  | Love and Other Drugs (2010) | £1,606,253 | £1,606,253 | £1,606,253 | new | 1 |
| 4 (new) |  | The Way Back (2010) | £1,327,650 | £1,327,650 | £1,327,650 | new | 1 |
| 5 (2) |  | The Chronicles of Narnia: The Voyage of the Dawn Treader (2010) | £1,207,264 | £3,785,959 | £11,263,418 | 23% | 4 |
| 6 (3) |  | TRON Legacy (2010) | £1,059,569 | £3,284,617 | £7,371,361 | 54% | 3 |
| 7 (4) |  | Harry Potter and the Deathly Hallows Part 1 (2010) | £1,040,826 | £2,119,836 | £48,914,777 | 60% | 7 |
| 8 (6) |  | Megamind (2010) | £612,327 | £1,695,090 | £8,378,843 | 50% | 5 |
| 9 (7) |  | The Tourist (2010) | £396,758 | £1,083,209 | £4,702,790 | 58% | 4 |
| 10 (8) |  | Animals United (2010) | £243,442 | £751,387 | £1,736,166 | 35% | 3 |
| 11 (10) |  | Burlesque (2010) | £183,023 | £673,641 | £1,610,646 | 55% | 3 |
| 12 (9) |  | Arthur and the Great Adventure (2010) | £130,582 | £379,522 | £463,397 | 36% | 2 |
| 13 (5) |  | Tees Maar Khan (2010) | £98,033 | £304,599 | £624,469 | -69% | 2 |
| 14 (12) |  | Fred: The Movie (2010) | £85,877 | £294,930 | £838,616 | 48% | 3 |
| 15 (15) |  | Unstoppable (2010) | £31,407 | £89,019 | £4,614,199 | 41% | 6 |