| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | The Secret Life of Pets (2016) | £9,580,039 | £9,580,039 | £9,580,039 | new | 1 |
| 2 (new) |  | Independence Day: Resurgence (2016) | £5,067,855 | £5,067,855 | £5,067,855 | new | 1 |
| 3 (1) |  | The Conjuring 2: The Enfield Case (2016) | £1,563,015 | £3,097,191 | £7,735,053 | -66% | 2 |
| 4 (2) |  | Me Before You (2016) | £669,924 | £1,486,129 | £8,023,271 | -32% | 4 |
| 5 (6) |  | The Nice Guys (2016) | £202,580 | £440,017 | £3,467,375 | -51% | 4 |
| 6 (5) |  | Alice Through the Looking Glass (2016) | £189,077 | £402,855 | £9,395,165 | -55% | 5 |
| 7 (4) |  | Teenage Mutant Ninja Turtles: Out of the Shadows (2016) | £185,584 | £344,814 | £5,823,141 | -58% | 4 |
| 8 (7) |  | X-Men: Apocalypse (2016) | £173,187 | £359,786 | £18,120,476 | -54% | 6 |
| 9 (11) |  | The Jungle Book (2016) | £105,258 | £199,777 | £45,629,603 | -55% | 11 |
| 10 (9) |  | The Boss (2016) | £103,033 | £325,489 | £1,603,314 | -65% | 3 |
| 11 (3) |  | Gods of Egypt (2016) | £97,496 | £341,084 | £825,551 | -80% | 2 |
| 12 (10) |  | The Angry Birds Movie (2016) | £95,958 | £190,511 | £9,929,464 | -60% | 7 |
| 13 (8) |  | Warcraft (2016) | £88,744 | £259,969 | £5,947,228 | -72% | 4 |
| 14 (new) | | Elvis & Nixon (2016) | £56,790 | £56,790 | £56,790 | new | 1 |
| 15 (new) | | Sardaarji 2 (2016) | £56,382 | £56,382 | £56,382 | new | 1 |