| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | The Hitman's Wife's Bodyguard (2021) | £1,636,128 | £1,636,128 | £1,636,128 | new | 1 |
| 2 (2) |  | Peter Rabbit 2: The Runaway (2021) | £1,115,199 | £1,343,476 | £15,288,119 | 28% | 5 |
| 3 (new) |  | In the Heights (2021) | £1,073,687 | £1,073,687 | £1,073,687 | new | 1 |
| 4 (1) |  | A Quiet Place: Part II (2021) | £1,024,942 | £1,917,822 | £8,339,827 | -22% | 3 |
| 5 (3) |  | Cruella (2021) | £731,639 | £1,108,404 | £7,024,010 | 0% | 4 |
| 6 (4) |  | The Conjuring: The Devil Made Me Do It (2021) | £494,713 | £946,278 | £7,726,651 | -26% | 4 |
| 7 (6) |  | The Father (2021) | £338,408 | £758,135 | £1,155,553 | -15% | 2 |
| 8 (5) |  | Nobody (2021) | £201,033 | £444,478 | £1,018,877 | -65% | 2 |
| 9 (new) |  | Monster Hunter (2020) | £150,077 | £150,077 | £150,077 | new | 1 |
| 10 (7) |  | Godzilla Vs. Kong (2021) | £76,192 | £119,253 | £2,549,257 | -32% | 5 |
| 11 (12) |  | Raya and the Last Dragon (2021) | £71,225 | £82,541 | £687,116 | 42% | 5 |
| 12 (9) |  | Tom & Jerry: The Movie (2021) | £63,482 | £71,371 | £845,526 | 16% | 5 |
| 13 (new) |  | In the Earth (2021) | £58,538 | £58,538 | £58,538 | new | 1 |
| 14 (10) |  | Nomadland (2021) | £35,190 | £89,057 | £1,935,525 | -19% | 5 |
| 15 (8) |  | Dream Horse (2021) | £26,036 | £108,198 | £586,395 | -67% | 3 |