UK Box Office 22nd October, 2021
| Title | Weekend | Week | Total | % Change | Total Weeks | ||
| 1 (new) |  | Dune (2021) | £5,876,892 | £5,876,892 | £5,876,892 | new | 1 |
| 2 (1) |  | No Time To Die (2021) | £4,672,560 | £9,447,815 | £78,027,818 | -44% | 4 |
| 3 (2) |  | Venom: Let There Be Carnage (2021) | £2,470,168 | £5,025,362 | £11,193,195 | -60% | 2 |
| 4 (new) |  | The Boss Baby 2: Family Business (2021) | £1,193,114 | £1,193,114 | £1,193,114 | new | 1 |
| 5 (4) |  | The Addams Family 2 (2021) | £885,404 | £1,361,511 | £5,289,699 | -36% | 3 |
| 6 (new) |  | The French Dispatch of the Liberty, Kansas Evening Sun (2021) | £867,672 | £867,672 | £867,672 | new | 1 |
| 7 (3) |  | Halloween Kills (2021) | £771,657 | £1,597,715 | £3,195,777 | -52% | 2 |
| 8 (5) |  | Ron's Gone Wrong (2021) | £562,540 | £921,201 | £1,789,254 | -35% | 2 |
| 9 (new) |  | Dear Evan Hansen (2021) | £236,396 | £236,396 | £236,396 | new | 1 |
| 10 (8) |  | Honsla Rakh (2021) | £78,150 | £146,422 | £268,079 | -36% | 2 |
| 11 (7) |  | Shang-Chi and the Legend of the Ten Rings (2021) | £60,763 | £163,187 | £21,124,328 | -67% | 8 |
| 12 (6) |  | The Last Duel (2021) | £58,850 | £332,646 | £658,168 | -82% | 2 |
| 13 (9) |  | The PAW Patrol: Movie (2021) | £43,974 | £67,242 | £8,478,200 | -38% | 11 |
| 14 (14) |  | Hocus Pocus (1993) Rerelease | £24,296 | £24,296 | £351,437 | -2% | 18 |
| 15 (12) |  | Deadly Cuts (2021) | £15,499 | £36,931 | £162,437 | -43% | 3 |