| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Eternals (2021) | £2,918,585 | £5,114,598 | £10,571,175 | -47% | 2 |
| 2 (2) |  | No Time To Die (2021) | £1,567,870 | £2,848,921 | £92,717,959 | -21% | 7 |
| 3 (3) |  | Dune (2021) | £1,172,873 | £2,131,651 | £18,942,227 | -24% | 4 |
| 4 (6) |  | Spencer (2021) | £698,065 | £1,039,775 | £1,532,418 | 29% | 2 |
| 5 (5) |  | The Boss Baby 2: Family Business (2021) | £574,218 | £652,802 | £6,477,199 | -5% | 4 |
| 6 (4) |  | Venom: Let There Be Carnage (2021) | £524,169 | £888,584 | £17,091,466 | -22% | 5 |
| 7 (7) |  | The Addams Family 2 (2021) | £334,176 | £387,442 | £9,907,371 | -23% | 6 |
| 8 (9) |  | Ron's Gone Wrong (2021) | £276,666 | £299,079 | £4,272,807 | 3% | 5 |
| 9 (8) |  | The French Dispatch of the Liberty, Kansas Evening Sun (2021) | £267,190 | £538,564 | £3,393,121 | -21% | 4 |
| 10 (10) |  | Last Night In Soho (2021) | £181,247 | £421,606 | £1,920,809 | -31% | 3 |
| 11 (new) |  | Mothering Sunday (2021) | £156,940 | £156,940 | £156,940 | new | 1 |
| 12 (new) | | Kurup (2021) | £132,180 | £132,180 | £132,180 | new | 1 |
| 13 (11) |  | Sooryavanshi (2021) | £120,827 | £230,548 | £441,122 | -43% | 2 |
| 14 (new) | | Wesele (2021) | £74,118 | £74,118 | £74,118 | new | 1 |
| 15 (new) |  | Cry Macho (2021) | £72,130 | £72,130 | £72,130 | new | 1 |