| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | House of Gucci (2021) | £2,425,627 | £2,425,627 | £2,425,627 | new | 1 |
| 2 (1) |  | Ghostbusters: Afterlife (2021) | £2,099,374 | £3,199,591 | £7,513,854 | -51% | 2 |
| 3 (new) |  | Encanto (2021) | £1,720,132 | £1,720,132 | £1,720,132 | new | 1 |
| 4 (2) |  | Eternals (2021) | £586,304 | £1,044,864 | £13,871,120 | -52% | 4 |
| 5 (3) |  | No Time To Die (2021) | £492,635 | £1,001,932 | £95,491,106 | -48% | 9 |
| 6 (4) |  | Dune (2021) | £413,585 | £768,795 | £20,954,264 | -35% | 6 |
| 7 (new) |  | Anything Goes: The Musical (2021) | £371,879 | £371,879 | £371,879 | new | 1 |
| 8 (5) |  | King Richard (2021) | £250,142 | £558,437 | £1,128,753 | -56% | 2 |
| 9 (6) |  | The Boss Baby 2: Family Business (2021) | £137,959 | £164,362 | £7,050,766 | -61% | 6 |
| 10 (8) |  | Venom: Let There Be Carnage (2021) | £122,442 | £254,236 | £17,851,824 | -56% | 7 |
| 11 (new) |  | A Boy Called Christmas (2021) | £120,770 | £120,770 | £120,770 | new | 1 |
| 12 (11) |  | The French Dispatch of the Liberty, Kansas Evening Sun (2021) | £81,228 | £199,426 | £3,934,943 | -50% | 6 |
| 13 (7) |  | Spencer (2021) | £69,495 | £302,028 | £2,664,635 | -77% | 4 |
| 14 (new) | | Antim (2021) | £60,874 | £60,874 | £60,874 | new | 1 |
| 15 (new) | | Maanaadu (2021) | £54,898 | £54,898 | £54,898 | new | 1 |