| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Spider-Man: No Way Home (2021) | £6,055,345 | £18,742,219 | £69,849,930 | 24% | 3 |
| 2 (new) |  | The King's Man (2021) | £3,496,627 | £3,496,627 | £3,496,627 | new | 1 |
| 3 (3) |  | Clifford the Big Red Dog (2021) | £778,802 | £2,158,567 | £5,982,503 | 55% | 4 |
| 4 (2) |  | The Matrix Resurrections (2021) | £760,427 | £2,608,138 | £5,294,923 | -72% | 2 |
| 5 (4) |  | West Side Story (2021) | £397,792 | £1,234,014 | £5,087,727 | 47% | 4 |
| 6 (6) |  | Encanto (2021) | £241,873 | £702,248 | £6,168,091 | 35% | 6 |
| 7 (12) |  | House of Gucci (2021) | £139,718 | £403,921 | £8,753,878 | 66% | 6 |
| 8 (11) |  | Ghostbusters: Afterlife (2021) | £127,872 | £340,920 | £11,053,586 | 54% | 7 |
| 9 (new) |  | Titane (2021) | £121,920 | £121,920 | £121,920 | new | 1 |
| 10 (5) |  | '83 (2021) | £85,909 | £268,424 | £450,942 | -53% | 2 |
| 11 (new) |  | The Electrical Life of Louis Wain (2021) | £85,763 | £85,763 | £85,763 | new | 1 |
| 12 (new) | | Cinderella: Met Opera 2022 (2021) | £23,039 | £23,039 | £23,039 | new | 1 |
| 13 (re) |  | The Boss Baby 2: Family Business (2021) | £22,601 | £22,601 | £7,200,480 | RE | 9 |
| 14 (16) |  | No Time To Die (2021) | £14,786 | £72,585 | £96,555,145 | 34% | 14 |
| 15 (new) |  | The Humans (2021) | £14,230 | £14,230 | £14,230 | new | 1 |