UK Box Office 31st December, 2021
| Title | Weekend | Week | Total | % Change | Total Weeks | ||
| 1 (1) |  | Spider-Man: No Way Home (2021) | £6,055,345 | £18,742,219 | £69,849,930 | 24% | 3 |
| 2 (new) |  | The King's Man (2021) | £3,496,627 | £3,496,627 | £3,496,627 | new | 1 |
| 3 (3) |  | Clifford the Big Red Dog (2021) | £778,802 | £2,158,567 | £5,982,503 | 55% | 4 |
| 4 (2) |  | The Matrix Resurrections (2021) | £760,427 | £2,608,138 | £5,294,923 | -72% | 2 |
| 5 (4) |  | West Side Story (2021) | £397,792 | £1,234,014 | £5,087,727 | 47% | 4 |
| 6 (6) |  | Encanto (2021) | £241,873 | £702,248 | £6,168,091 | 35% | 6 |
| 7 (12) |  | House of Gucci (2021) | £139,718 | £403,921 | £8,753,878 | 66% | 6 |
| 8 (11) |  | Ghostbusters: Afterlife (2021) | £127,872 | £340,920 | £11,053,586 | 54% | 7 |
| 9 (new) |  | Titane (2021) | £121,920 | £121,920 | £121,920 | new | 1 |
| 10 (5) |  | '83 (2021) | £85,909 | £268,424 | £450,942 | -53% | 2 |
| 11 (new) |  | The Electrical Life of Louis Wain (2021) | £85,763 | £85,763 | £85,763 | new | 1 |
| 12 (new) | Cinderella: Met Opera 2022 (2021) | £23,039 | £23,039 | £23,039 | new | 1 | |
| 13 (re) |  | The Boss Baby 2: Family Business (2021) | £22,601 | £22,601 | £7,200,480 | RE | 9 |
| 14 (16) |  | No Time To Die (2021) | £14,786 | £72,585 | £96,555,145 | 34% | 14 |
| 15 (new) |  | The Humans (2021) | £14,230 | £14,230 | £14,230 | new | 1 |
| 16 (re) |  | Antarctica (2020) | £9,398 | £9,398 | £395,579 | RE | 19 |
| 17 (31) |  | The Gruffalos Child w/ Stick Man (2021) | £8,586 | £10,761 | £22,713 | 95% | 5 |
| 18 (re) | Kinky Boots: The Musical (2020) | £6,194 | £6,194 | £1,467,037 | RE | 20 | |
| 19 (21) |  | The French Dispatch of the Liberty, Kansas Evening Sun (2021) | £4,427 | £13,242 | £4,133,305 | 53% | 11 |
| 20 (10) |  | A Boy Called Christmas (2021) | £4,399 | £28,977 | £825,564 | -92% | 6 |
| 21 (18) | Boxing Day (2021) | £2,819 | £12,410 | £640,582 | -66% | 5 | |
| 22 (re) |  | Pirates (2021) | £2,581 | £2,581 | £98,689 | RE | 4 |
| 23 (20) |  | Paddington (2014) Rerelease 2021 | £2,116 | £9,335 | £18,401 | 2% | 51 |
| 24 (new) | Kunjeldo (2021) | £2,055 | £2,055 | £2,055 | new | 1 | |
| 25 (30) |  | Ron's Gone Wrong (2021) | £2,010 | £5,857 | £4,618,622 | 71% | 12 |
| 26 (re) |  | Harry Potter and the Philosopher's Stone (2001) 20th Anniversary | £1,781 | £1,781 | £1,323,543 | RE | 42 |
| 27 (re) |  | Hey Duggee At the Cinema 2 (2021) | £1,662 | £1,662 | £76,375 | RE | 10 |
| 28 (24) |  | Bing's Christmas and Other Stories (2020) | £1,366 | £10,565 | £75,777 | -21% | 8 |
| 29 (re) |  | Spencer (2021) | £1,024 | £1,024 | £2,822,348 | RE | 8 |
| 30 (re) | The Nutcracker: ROH London 2021 (2021) | £647 | £647 | £426,919 | RE | 2 | |
| 31 (28) |  | Timmy's Cinema Adventure: Christmas Edition (2021) | £555 | £2,776 | £25,609 | -49% | 6 |
| 32 (re) |  | Mothering Sunday (2021) | £340 | £340 | £495,414 | RE | 7 |
| 33 (re) |  | Last Night In Soho (2021) | £240 | £240 | £2,328,881 | RE | 9 |
| 34 (re) |  | Herself (2020) | £207 | £207 | £283,049 | RE | 8 |
| 35 (re) |  | Censor (2021) | £191 | £191 | £169,150 | RE | 6 |
| 36 (re) | Limbo (2021) | £162 | £162 | £297,524 | RE | 2 | |
| 37 (re) | Rebel Dykes (2021) | £138 | £138 | £34,027 | RE | 3 | |
| 38 (re) | Arsène Wenger: Invincible (2021) | £81 | £81 | £34,106 | RE | 5 | |
| 39 (29) |  | Eternals (2021) | £78 | £16,536 | £14,869,370 | -89% | 9 |
| 40 (re) | Poly Styrene: I Am a Cliche (2021) | £66 | £66 | £3,989 | RE | 6 | |
| 41 (re) | The Reason I Jump (2021) | £59 | £59 | £76,776 | RE | 13 | |