Tom Hanks
Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins / Cavendish Look-a-Like Actor / Zachry
Halle Berry
Native Woman / Jocasta Ayrs / Luisa Rey / Indian Party Guest / Ovid / Meronym
Jim Broadbent
Captain Molyneux / Vyvyan Ayrs / Timothy Cavendish / Korean Musician / Prescient 2
Hugo Weaving
Haskell Moore / Tadeusz Kesselring / Bill Smoke / Nurse Noakes / Boardman Mephi / Old Georgie
Jim Sturgess
Adam Ewing / Poor Hotel Guest / Megan's Dad / Highlander / Hae-Joo Chang / Adam (Zachry's Brother-in-Law)
Bae Doona
Tilda / Megan's Mom / Mexican Woman / Sonmi-451 / Sonmi-351 / Sonmi Prostitute
Ben Whishaw
Cabin Boy / Robert Frobisher / Store Clerk / Georgette / Tribesman
Keith David
Kupaka / Joe Napier / An-kor Apis / Prescient
James D'Arcy
Young Rufus Sixsmith / Old Rufus Sixsmith / Nurse James / Archivist
Xun Zhou
Talbot (Hotel Manager) / Yoona-939 / Rose
David Gyasi
Autua / Lester Rey / Duophysite
Susan Sarandon
Madame Horrox / Older Ursula / Yusouf Suleiman / Abbess
Hugh Grant
Rev. Giles Horrox / Hotel Heavy / Lloyd Hooks / Denholme Cavendish / Seer Rhee / Kona Chief
Robert Fyfe
Old Salty Dog / Mr. Meeks / Prescient 1
Martin Wuttke
Mr. Boerhaave / Guard / Leary the Healer
Robin Morrissey
Young Cavendish
Brody Nicholas Lee
Javier Gomez / Jonas / Zachry's Older Nephew
Ian van Temperley
Enforcer
Andrew Havill
Mr. Hotchkiss
Tanja de Wendt
Mrs. Hotchkiss
Raevan Lee Hanan
Little Girl with Orison at Papa Song's / Catkin / Zachry Relative 1
Gotz Otto
Groundsman Withers
Niall Greig Fulton
Haskell Moore's Dinner Guest 2 / Mozza Hoggins
Louis Dempsey
Haskell Moore's Dinner Guest 3 / Jarvis Hoggins
Martin Docherty
Haskell Moore's Dinner Guest 4 / Eddie Hoggins
Alistair Petrie
Haskell Moore's Dinner Guest 1 / Musician / Felix Finch / Lascivious Businessman
Zhu Zhu
Megan Sixsmith / 12th Star Clone
Sylvestra Le Touzel
Haskell Moore's Dinner Guest 5 / Nurse Judd / Aide in Slaughtership
Jojo Schoning
Papa Song Punk
Laura Vietzen
Young Ursula
Thomas Kugel
Ursula's Father
Marie Ronnebeck
Ursula's Daughter
Emma Werz
Ursula's Granddaughter
Korbyn Hawk Hanan
Adam Grandson
Dulcie Smart
Ursula's Mother / Herbalist
Anna Holmes
Scientist / Executive
Genevien Lee
Zachry Relative
Cody Benjamin Lee
Zachry Relative
Heike Hanold-Lynch
Nurse Judd Look-a-Like
Kristoffer Fuss
Lead Enforcer
Marco Albrecht
Scan Enforcer
Gary McCormack
Crane Operator
Hannah Cooper-Dean
News Reporter
Jon Donahue
Moore's Accountant / Finch's Friend
Valerie Lillibeth
Muse of the Lemon Prize Winner
Joseph Anthony McKenna
Maudsley
Phoenix Melville
Young Novelist
Jeremy Paxman
Self - Newscaster
Daniele Rizzo
Co-Worker in San Francisco
Lyly Schoettle
Heroclone 02
Adam Siviter
Hoggins Impersonator
Nikko Weidemann
Vibraphonist
Alexander Yassin
Board Member / Indian Party Guest / Papa Song Guest
